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Benoquin® Cream

Benoquin® Cream

Benoquin® Cream is a skin depigmenting treatment used for extensive vitiligo. This topical medication having very potent skin decolorizing properties is formulated for adults and children over 12 years of age.  Show full description

Active ingredients

Other names for this medication

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Benoquin® Cream (Monobenzone) 20%, 20 g

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Benoquin® Cream is manufactured by Mac Remedies. This is a topical treatment for final depigmentation in extensive vitiligo. Benoquin® Cream permanently bleaches normal skin surrounding the pale areas associated with the disseminated (covering more than 50% of the body) idiopathic vitiligo.

Vitiligo occurs when the immune system produces antibodies to organism’s own melanocytes, cells producing melanin. Melanin is a pigment responsible for skin and hair coloring. When this pigment is suppressed by antibodies, random areas of the skin start losing its normal color and become very pale or even white.

Benoquin® Cream is not a cosmetic skin bleach and it must not be used to replace hydroquinone. It is not used for hyperpigmentation, melasma, chloasma, "liver spots", "age spots", and freckles.

Benoquin® Cream contains Monobenzone as its key ingredient. Monobenzone is a monobenzyl ether of hydroquinone and and a topical depigmenting agent.

MOA (mechanism of action):

In topical administration, Monobenzone causes permanent melanocytes destruction. With the suppression of melanocytes, these cells are no longer able to synthesize enough melanin needed for usual skin complexion. Normal skin around vitiliginous lesions start bleaching and over time matches the paler areas of the skin. Such effect of Monobenzone also called permanent irreversible depigmentation.


Benoquin® Cream is for external use only. Do not apply to your eyes, mouth, inside of the nose, private parts, and any other mucosal surface.

Benoquin® Cream is normally applied 2-3 times daily, usually for 1-4 months. After the desired level of skin depigmentation is achieved, Benoquin® Cream should be applied twice a week to maintain the depigmented skin complexion.

How to use Benoquin® Cream:

1. Wash your hands and make sure the affected areas are clean and dry.

2. Take a small amount of the cream and gently rub it over the affected area avoiding mucosal surfaces.

3. Wash your hands after the cream application.


Do not use more than 4 months if there are no satasfactory results.

After the therapy with Benoquin® Cream the skin becomes sensitive for the rest of the patient’s life. Use of sunscreen (SPF 15 at least) during and after the Benoquin® Cream treatment course is necessary prior to sun exposure.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not apply a double dose.


Do not exceed the doctor's recommended dose. If an overdose occurs and you are feeling unwell, you should seek emergency medical attention or contact your healthcare provider immediately.


Store at a room temperature from 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away the tube after the expiration date. Keep away from children.

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Side effects

The most common side effects associated with the use of Benoquin® Cream are:

  • allergic reactions
  • mild irritation and sensitization
  • burning sensation
  • dermatitis

Side effects occurrence does not only depend on the medication you are using, but also on your overall health and other factors.


Do not apply Benoquin® Cream if you are allergic to Monobenzone.

Do not apply Benoquin® Cream if you are allergic to any of the other ingredients comprised in Benoquin® Cream.

Do not use Benoquin® Cream for freckling, berlock dermatitis, melasma (chloasma), hyperpigmentation resulting from inflammation of the skin, café au lait spots, pigmented nevi, malignant melanoma or pigmentation resulting from pigments other than melanin.

Consult your doctor if you want to use Benoquin® Cream during pregnancy or breastfeeding. Benoquin® Cream should be used in pregnant or lactating women only if clearly needed.

Do not use Benoquin® Cream in patients under the age of 12.

Do not take by mouth. Benoquin® Cream is for use only on the skin.

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Frequently asked questions

Q: Can I use Benoquin® Cream to treat freckles?

A: No. Benoquin® Cream can be used only for final depigmentation in extensive Vitiligo and nothing else.

Q: Can I use Benoquin® Cream for my child?

A: Benoquin® Cream can be used in children over 12 years of age.

Q: Is Benoquin® Cream safe?

A: Benoquin® Cream is completely safe as long as used at prescribed doses for the prescribed duration as advised by your doctor.

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Target PointShipping MethodTrackingDelivery TimePrice

Worldwide Shipping

  Not trackable14-21 business days$20.00 per order
  Trackable, where available5-9 business days$30.00 per order

Delivery time is:

Registered Mail - 14-21 business days price - $20.00, no signature is required on delivery.
EMS - 5-9 business days price - $30.00, signature is required on delivery.
Your order will be packed safe and secure and dispatched within 24 hours.

This is exactly how your parcel will look like (pictures of a real shipping item). It has a look of a regular private letter and does not disclose its contents. Size - 9.4x4.3x0.3 inches (24x11x0.7cm).

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