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Melacare® Cream

Melacare® Cream

Melacare® Cream is a topical medication for bleaching the darkened spots on the skin, also known as hyperpigmentation or melasma. This cream is a triple combination of retinoid, corticosteroid, and strong skin lightening agent. Melacare® Cream is formulated for use in adults and children over 12 years of age.  Show full description

Active ingredients

Other names for this medication

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Melacare® Cream (Hydroquinone) 2% + 0.1% + 0.025%, 15 g

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Melacare® Cream is manufactured by Ajanta. This is an anti-pigmentation topical treatment used to lighten the darkened areas of the skin, including freckles, chloasma (also known as melasma), age spots, liver spots and even acne scars. The active ingredients of Melacare® Cream are Hydroquinone, Tretinoin, and Mometasone Furoate. Hydroquinone is a benzene derivative of phenol type. Applied to the darkened areas of skin, it acts as a bleaching agent. Tretinoin is a retinoid and vitamin A (retinol) derivative with keratolytic and comedolytic properties. Mometasone Furoate is a corticosteroid of glucocorticoid class with strong anti-inflammatory activity.

Hyperpigmentation is a formation of light to medium brown patches on the skin. It is caused by an overproduction of melanin (naturally produced pigment). Hyperpigmentation is thought to develop due to genetic predisposition, sun exposure, pregnancy, hormone treatments, skin trauma, use of perfumes and deodorants, and hypothyroidism (low thyroid hormone).

MOA (mechanism of action):

Hydroquinone inhibits tyrosinase, the enzyme responsible for melanin production and breaks down the melanin pigment granules in the skin pigment cells (melanocytes), thereby allowing brown patches come back to a normal complexion.

Tretinoin binds to specific retinoic acid receptors and regulates cell growth and differentiation. It promotes skin cells production and peels off the old epithelial cells. By these actions, Tretinoin speeds up the cells turnover rate and makes the lightening of the skin more rapid.

Mometasone Furoate blocks the release of inflammatory mediators, such as prostaglandins and leukotrienes. It also decreases the risk of contact dermatitis development that may appear due to the Hydroquinone and Tretinoin application.


Melacare® Cream is for external use only. Do not apply to your eyes, mouth, inside of the nose, private parts, and any other mucosal surface.

Melacare® Cream should be applied 1-2 times daily, preferably in the morning and at bedtime.

Melacare® Cream is usually applied from several weeks to 2-3 months depending on skin condition and tolerance. Use Melacare® Cream as long as recommended by your doctor.

How to use Melacare® Cream:

1. Wash your hands and make sure the affected areas are clean and dry.

2. Take a small amount of the cream and gently massage it over the affected area avoiding mucosal surfaces.

3. Wash your hands after the cream application.


Do not use Melacare® Cream for longer than 6 months.

You should use sunscreen product (SPF 15 at least) during the Melacare® Cream treatment course.

If you need to treat a large area of the skin with Melacare® Cream, divide the application into a few sessions. Do not apply this cream to large areas at once.

If you have sensitive skin, it is recommended to test the sensitivity to Melacare® Cream. Apply a small amount of the cream to the inner side of your arm and wait for 24 hours. If no hypersensitivity reactions occur (such as severe itching, burning, swelling, vesicle formation, and inflammation), you can start the regular Melacare® Cream treatment course.

Do not apply Melacare® Cream to the irritated, itchy, cracked or burnt skin (sunburns and windburns included).

Do not cover the Melacare® Cream application site with occlusive bandages or other covering.

Do not use Melacare® Cream in combination with harsh skin products, medicated soaps and shampoos, products with drying effect on the skin, peeling agents, products containing alcohol, spices or lime.

Do not get permanent wave solutions and waxing products on skin being treated with Melacare® Cream.

Do not apply skin moisturizers or makeup to the skin being treated with Melacare® Cream 1 hour before and after the gel application.

Patients should use sunscreens (min. SPF 15) and protective clothing while using Melacare® Cream.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not apply a double dose.


Do not exceed the doctor's recommended dose. If an overdose occurs and you are feeling unwell, you should seek emergency medical attention or contact your healthcare provider immediately.


Store at a room temperature from 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away the tube after the expiration date. Keep away from children.

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Side effects

The most common side effects associated with the use of Melacare® Cream are:

  • dry skin
  • itchiness
  • irritated skin
  • burning or stinging sensation
  • scaling
  • skin rash
  • contact dermatitis

Side effects occurrence does not only depend on the medication you are using, but also on your overall health and other factors.


Do not apply Melacare® Cream if you are allergic to Hydroquinone, Tretinoin or Mometasone Furoate.

Do not apply Melacare® Cream if you have a history of severe allergic reactions associated with the use of retinoids, corticosteroids or skin bleaching products.

Do not apply Melacare® Cream if you are allergic to any of the other ingredients comprised in Melacare® Cream.

Do not apply Melacare® Cream if you eczema, rosacea, hepatic disease or perioral dermatitis.

Do not use Melacare® Cream if you or any of your family members have ever had an epidermal tumor.

Do not use Melacare® Cream if you are taking any pain medications (aspirin, ibuprofen, meloxicam, tramadol), asthma drugs (albuterol), antibiotics (clindamycin, doxycycline, minocycline), peroxides, omega-3 polyunsaturated fatty acids (fish oil), muscle relaxers (cyclobenzaprine), corticosteroids (fluticasone, prednisone), epilepsy drugs (gabapentin, clonazepam), hormones (melatonin), stomach drugs (omeprazole), antidepressants (trazodone, alprazolam) or antihistamines (cetirizine).

Do not use Melacare® Cream if you have skin cancer, skin photosensitivity disorder, sunburn or sunlight (UV) exposure.

Do not apply Melacare® Cream if you have sunburn, windburn or skin irritation with redness, peeling or itching.

Melacare® Cream is strictly prohibited for women who are pregnant, planning to have a baby or breastfeeding.

Do not use Melacare® Cream in patients under the age of 12.

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Frequently asked questions

Q: What Melacare® Cream is used for?

A: Melacare® Cream is used to treat melasma also known as hyperpigmentation of the skin.

Q: Is Melacare® Cream safe for children?

A: Melacare® Cream is safe for patients over 12 years old as long as used for prescribed condition and at prescribed doses.

Q: Can Melacare® Cream be used in pregnant women?

A: Melacare® Cream is strictly prohibited for women who are pregnant, planning to have a baby or breastfeeding.

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  Not trackable14-21 business days$20.00 per order
  Trackable, where available5-9 business days$30.00 per order

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This is exactly how your parcel will look like (pictures of a real shipping item). It has a look of a regular private letter and does not disclose its contents. Size - 9.4x4.3x0.3 inches (24x11x0.7cm).

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